Adipogenesis: Signaling Pathways, Molecular Regulation and Impact on Human Disease

Yunfeng Lin, MD, PhD and Xiaoxiao Cai (Editors)
Sichuan University, Sichuan, China

Series: Cell Biology Research Progress
BISAC: SCI017000

Clear

$179.00

Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

eBook

Digitally watermarked, DRM-free.
Immediate eBook download after purchase.

Product price
Additional options total:
Order total:

Quantity:

Details

Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. Adipogenesis has been one of the most intensively studied models of cellular differentiation. The exact mechanisms of adipogenesis remain unclear, since it involves abundant gene, growth factors, cytokines and environmental factors.

This book provides an in-depth overview of current knowledge about the subject of adipogenesis in the human body, including what is known about molecular mechanisms (e.g. cytokine- and growth-factor-related). Transcriptional regulators control the expression of target genes by the interaction with cofactors, coactivators, chromatin remodelling complexes and also with general transcriptional machinery.

Current data suggests that adipogenesis is regulated by complex signaling pathway interactions involving multiple transcription factors. Many signaling pathways follow an inverse relationship between osteogenic and adipogenic differentiation. To provide better insight into the basic mechanisms of MSC fate determination, it is crucial to understand the various signaling pathways and cytokine interactions that coordinate this process. Further elucidation of this dichotomy may both improve understanding of human disease and speed the realization of MSC mediated tissue engineering.

There are a number of gaps in current knowledge of how adipogenesis actually occurs, and the authors are hopeful that the publication of this book will help researchers in this field to decide where to focus their future efforts. Contributions are therefore sought from anyone who is undertaking research in this area. The book will also provide an overview for surgeons and clinicians who wish to be kept abreast of developments in this fascinating subject. (Imprint: Nova Biomedical )

Chapter 1. Molecular Determination of Adipogenic versus Osteogenic Differentiation in Mesenchymal Stem Cells
(Alan Nguyen, Le Chang, Michelle A. Scott and Aaron W. James, Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA)

Chapter 2. LMNA-Linked Lipodystrophies: Experimental Models to Unravel the Molecular Mechanisms
(Arantza Infante, Garbiñe Ruiz de Eguino, Andrea Gago and Clara I. Rodríguez, Stem Cells and Cell Therapy Laboratory, BioCruces Health Research Institute, Hospital Universitario Cruces, Bizkaia, Spain)

Chapter 3. Adipogenesis and Osteoblastgenesis toward the Ageing Intervention in the 21st Century
(Takeshi Imai, Department Head of Aging Intervention, National Center for Geriatrics and Gerontology, Japan)

Chapter 4. Role of Wnt/β-Catenin Signaling in Bone Marrow Adiposity Following Cancer Chemotherapy
(Kristen R. Georgiou and Cory J. Xian, Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia)

Chapter 5. Role of Reactive Oxygen Species in Adipocyte Differentiation
(D. Lettieri-Barbato, K. Aquilano, G. Tatulli and M.R. Ciriolo, Department of Biology, University of Rome Tor Vergata, Rome, Italy and others)

Chapter 6. Adipogenesis: Signaling Pathways, Molecular Regulation and Clinical Impact
(Kristin A. McPhillips and Quanjun Cui, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA)

Index

Audience: It is hoped that the publication of this book will help researchers in this field to decide where to focus their future efforts. Contributions are therefore sought from anyone who is undertaking research in this area. The book will also provide an overview for surgeons and clinicians who wish to be kept abreast of developments in this fascinating subject.

You have not viewed any product yet.