Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects

Vickram Ramkumar (Editor)
Department of Pharmacology, SIU School of Medicine, Springfield, IL, USA

Roberto Paes de Carvalho (Editor)
Universidade Federal Fluminense, Caixa, Niterói, RJ, Brazil

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

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Volume 10

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Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The role of adenosine and adenosine receptors in normal cell physiology and in diseases has been an area of active research over the last several decades. The field has advanced from the use of limited tools to examine receptor signaling and function to the use of various molecular and receptor knockout techniques to examine the details of the expression and functions and regulation of these receptors. This book highlights important milestones in adenosine receptor research and reviews recent findings from experts in different research areas. Several research areas, ranging from cardiovascular, cancer, and central nervous system research are discussed.

Several of the chapters describe how understanding the basic cellular mechanisms regulated by adenosine could lead to the development of important therapeutics. The editors, Vickram Ramkumar and Roberto Paes-de-Carvalho, have published extensively on adenosine receptors for more than two decades and are still active in this field of research. It is our hope that this book provides an excellent synopsis of the current status of adenosine receptor research which would be valuable for researchers in the field and as a reference source for clinicians and others interested in this area.
(Imprint: Nova Biomedical)

Preface

Chapter 1
Adenosine and Adenosine Receptors: An Overview
(Vickram Ramkumar, Sandeep Sheth and Srinivisan Tupal, Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA)

Chapter 2
Adenosine Membrane Transporters
(Natalia Grañé-Boladeras, Alex Bicket, Maliha Zafar, Alexandre dos Santos-Rodrigues, Imogen R. Coe, Department of Chemistry and Biology, Faculty of Science, Ryerson University, Toronto, ON, Canada, and others)

Chapter 3
Regulation of Adenosine Receptor Desensitisation and Function
(Claire Rutherford, Timothy M. Palmer, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom, and others)

Chapter 4
Adenosine Receptors in the Cardiovascular System
(Mark E. Olah, Department of Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, Ohio Northern University, Ada, OH, USA)

Chapter 5
Adenosine and Central Nervous System Development
(Roberto Paes-de-Carvalho, Mariana R. Pereira, Camila C. Portugal, Renato Socodato and Nádia A. de Oliveira, Program of Neurosciences and Department of Neurobiology, Fluminense Federal University, Niteroi, Brazil, and others)

Chapter 6
Adenosine in the Retina: Roles and Perspectives
(Rafael Brito, Danniel Pereira-Figueiredo, Elisa Guimarães-Souza, Alexandre dos Santos-Rodrigues and Karin C. Calaza, Neuroscience Program, Neurobiology Department, Fluminense Federal University, Brazil)

Chapter 7
The Adenosinergic System and its Interactions with Cytokines
(Rafael Perígolo-Vicente, Elizabeth Giestal-de-Araujo, Universidade Federal do Rio de Janeiro – Rio de Janeiro, Brazil, and others)

Chapter 8
Role of Adenosine Receptors in Cancer
(Sandeep Sheth, Srinivisan Tupal, Vickram Ramkumar, Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL, USA)

Chapter 9
Role of Adenosine Receptors in Auditory Functions
(Vickram Ramkumar, Vikrant Borse, Sumana Ghosh, Tejbeer Kaur, Kelly Sheehan, Sandeep Sheth, Asmita Dhukhwa, Srinivisan Tupal, Debashree Mukherjea and Leonard P. Rybak, Department of Pharmacology and 2Department of Surgery (Otolaryngology), Southern Illinois University School of Medicine, Springfield, IL, USA, and others)

Chapter 10
Adenosine Receptor Modulation of GABAergic Transmission
(Ana M. Sebastião, Diogo M. Rombo and Joaquim A. Ribeiro, Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, and others)
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Chapter 11
Adenosine Receptors, Oligomerization and Parkinson’s Disease Pharmacotherapy
(Francisco Ciruela, Leandra C. Constantino, Debora Lanzaster, Tharine Dal-Cim, Carla I. Tasca and Víctor Fernández-Dueñas, Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L’Hospitalet de Llobregat, 08907 Barcelona, Spain, and others)

Chapter 12
Adenosine Receptors in Neuroprotection Evoked by Pre- and Postconditioning
(Leandra C Constantino, Tharine Dal-Cim, Simone Molz, Francisco Ciruela, Carina R Boeck and Carla I Tasca, Departamento de Bioquímica, Programa de Pós-graduação em Bioquímica, Programa de Pós-graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, Florianópolis, SC, Brazil, and others)

Chapter 13
Functional Interactions of Adenosine Receptors and their Possible Implications in Central Nervous System Diseases
(Patrizia Popoli, Maria Rosaria Domenici, Alberto Martire and Maria Teresa Tebano, Section of Central Nervous System Pharmacology, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy)

Chapter 14
Emerging Roles for Adenosine in Nervous System Plasticity
(Henrique Rocha-Mendonça, Vanessa G. Goulart, Michele B. de Carvalho, Felipe Cabral-Miranda, Ana L. Tavares-Gomes, Paula Campello-Costa, Programa de Neurociências, Departamento de Neurobiologia, Instituto de Biologia, Universidade Federal Fluminense, Caixa Postal, Niterói, RJ, Brazil, and others)

Chapter 15
Adenosine Receptors: An Opportunity for Nanomedicine
(José Luis Albasanz and Mairena Martín, Departamento de Química Inorgánica, Orgánica y Bioquímica, Facultad de Ciencias y Tecnologías Químicas / Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Ciudad Real, Spain)

Index

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