Adenosine Receptors: Pharmacology, Functions and Therapeutic Aspects

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Kasandra Warrick (Editor)

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

Adenosine is a ubiquitous adenine base purine that mediates diverse biological and physiological processes in the cardiovascular system, both in cardiac and vascular tissues. Adenosine was reported to be involved in smooth muscle contraction, neurotransmission/neuromodulation, immune response and inflammation, platelet aggregation and modulation of cardiac function. Adenosine availability, in the extracellular space, depends on its release from a variety of cell types, as a result of adenosine triphosphate (ATP) enzymatic breakdown of both intra- and extracellular adenine nucleotides and intracellular S-adenosylhomocysteine. This book discusses the pharmacology, functions and therapeutic aspects of adenosine receptors.

(Imprint: Nova Biomedical)

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Table of Contents

Preface

Chapter I – Anti-Inflammatory and Immunosuppressive Actions of Adenosine A2A Receptor in Ischemia-Reperfusion Injury After Organ Transplantation (pp. 1-36)
Ashish K. Sharma, Gilbert R. Kinsey, Preeti Chhabra, Kenneth L. Brayman, Brent A. French, David K. Glover and Victor E. Laubach (Department of Surgery, University of Virginia, Charlottesville, VA, USA, and others)

Chapter II – Adenosine Receptors in the Vasculature: Physiology, Pharmacology and Therapeutic Perspectives (pp. 37-76)
J. B. Sousa, A. S. Soares, P. Fresco and C. Diniz (REQUIMTE/FARMA, Department of Drug Sciences, Laboratory of Pharmacology, University of Porto, Porto, Portugal, and others)

Chapter III – Insights on the Role of Adenosine and Adenosine Receptors on Melanoma: New Therapeutic Strategies (pp. 77-114)
A. S. Soares, J. B. Sousa, C. Diniz and P. Fresco (REQUIMTE/FARMA, Department of Drug Sciences, Laboratory of Pharmacology, University of Porto, Porto, Portugal, and others)

Chapter IV – Urinary Bladder Disorders: Is Adenosine Friend or Foe? (pp. 115-142)
M. Silva-Ramos, I. Silva, M. Faria, M. T. Magalhães-Cardoso and P. Correia-de-Sá (Laboratório de Farmacologia e Neurobiologia/UMIB, Portugal, and others)

Chapter V – Involvement of Deoxyadenosine and Adenosine Deaminase in the Methotrexate-Induced Suppression of Inflammatory Bone Destruction (pp. 143-164)
Peng-Fei Qu, Akiko Kukita, Yin-Ji Li, Kanako Moriyama, Lin Lei and Toshio Kukita (Department of Molecular Cell Biology & Oral Anatomy, Faculty of Dental Science, Kyushu University, Maidashi, Fuokuoka, Japan, and others)
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