Acetylcholine: Biochemistry, Functions and Role in Disease

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Jordan Mus (Editor)

Series: Neuroscience Research Progress
BISAC: MED057000

Due to its widespread expression, acetylcholine has been termed the “universal cytotransmitter”. The cholinergic system regulates the synthesis, actions and degradation of acetylcholine. In this compilation, the authors begin with a summary of the current literature on this topic.

Following this, a review of the results of studies examining the cholinergic hypothesis of central processes, either in stress reaction of humans or in depression induced by chronic social stresses, is provided. These studies include investigations performed by clinicians assessing the pathogenesis of depression and experiments with rodents.

In the closing study, an acetylcholine (ACh) biosensor based on acetylcholine oxidase (AChOx) on EDC activated thioglycolic acid self-assembled monolayer (TGA-SAM) using a tiny micro-chip is developed.

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Table of Contents

Preface

Chapter 1. Cholinergic Regulation during Infection
(Leon Islas Weinstein and Rogelio Hernández-PandoSection of Experimental Pathology, Department of Pathology, National Institute of Medical Sciences and Nutrition “Salvador Zubirán”, Mexico City, Mexico)

Chapter 2. Cholinergic Hypothesis of Depression and Stress Reaction of Organisms
(Tatiana B. Kalinnikova, Dilyara M. Khakimova, Anastasia V. Egorova, Rifgat R. Shagidullin and Marat Kh. Gainutdinov, Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, Kazan, Russia, and others)

Chapter 3. Selective Acetylcholine Biosensor Fabrication with Smart Bio-Chips
(Mohammed Muzibur Rahman, Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia)

Index

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