Table of Contents

ABSTRACT

Type 2 diabetes mellitus (T2DM) is a metabolic disease, marked by a high level of blood glucose and produced by insufficient or inefficient insulin secretary response. The adenosine binding cassette transporter proteins subfamily C member 8 (ABCC8) plays an essential role in insulin secretion from pancreatic beta cells. Dysfunction of this protein is associated with susceptibility to T2DM. Several studies reported the involvement of a number of single nucleotide polymorphisms (SNPs) of ABCC8 gene in susceptibility to T2DM. In this article, a systematic review and meta-analysis were carried out to precise evaluating of association of the ABCC8 rs757110, rs1799859, rs1801261 and rs1799854 polymorphisms with T2DM risk. Overall, 17 association studies of the rs757110 (5,281 cases, 4,869 controls), rs1799859 (1,486 cases, 2,005 controls), rs1801261 (747 cases, 892 controls) and rs1799854 (2,608 cases, 2,237 controls) polymorphisms relevance to T2DM published between 1996 and 2014 were eligible to include in this meta-analysis. Meta-analysis results showed significant association between rs1799854 and risk of diabetes under codominant (G/A vs. G/G: OR 0.81,95% CI 0.69-0.95, p = 0.008) and dominant (A/A+G/A vs. G/G: OR 0.83,95% CI 0.72-0.96, p = 0.01) models in Caucasians. G/G genotype was less common in patients with T2DM than in controls in all Caucasian studies (26% vs. 29%, respectively). GG genotype probably protects carriers against T2DM. In conclusion, ABCC8 rs1799854 polymorphism might be a risk factor for development of T2DM in Caucasian populations.

Keywords: type 2 diabetes, ABCC8, polymorphism, meta-analysis