A Handbook on Estrogen Receptors in the Brain

Vijay Paramanik, PhD
Assistant Professor, Indira Gandhi National Tribal University, Amarkantak, India

Series: Neuroscience Research Progress
BISAC: MED057000




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The present book covers estrogen, its receptors and estrogen mediated gene regulation in the brain. Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterized receptors: ERá and ERâ. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. When coregulators activate the transcription of a particular gene, they become coactivators; when they repress the activity of particular gene, they are called corepressors. These coregulators make a bridge between the basal transcription machinery and the receptors by protein-protein interaction. Estrogen disrupters are also explained in this book. Furthermore, the role of estrogen and its receptors are explained in the context of aging. Taken together, this book shall be self-explanatory concerning estrogen action in the brain in various aspects. Therefore, it is intended for researchers interested in the aforementioned aspects. (Imprint: Nova Biomedical)

Chapter 1. Introduction of Estrogen

Chapter 2. Synthesis of Estrogen

Chapter 3. Estrogen Receptors

Chapter 4. Different Types of Estrogen Receptors

Chapter 5. Mechanism of Estrogen Action

Chapter 6. Estrogen Disrupters

Chapter 7. Estrogen, ERs, Coregulators and Diseases

Chapter 8. Estrogen, ERs, Coregulators and Aging

Chapter 9. Conclusion

Chapter 10. Bibliography


Chapter 1

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Chapter 8

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