A Comprehensive Guide to Aptamers

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Tom Shuster (Editor)

Series: Life Sciences Research and Development
BISAC: SCI008000

This collection opens with a focus on recent advancements on the development of nucleic acid aptamers as alternative delivery systems for therapeutic oligonucleotides. Additionally, key examples of targeted delivery of the most common nucleic acid therapeutics, including small interfering RNAs, short hairpin RNAs, microRNAs and antisense oligonucleotides for a number of disorders are discussed.
The following chapter deals with in vivo studies that were conducted with radiopharmaceuticals based on aptamers, the radionuclides used, the radiolabeling strategies, the chemical modifications of interest to improve their properties, and the main aptamers advantages and drawbacks for application as radiopharmaceuticals.

In conclusion, the authors discuss the perspectives of using aptamers in various detection methods, their advantages and disadvantages, and the results of such work carried out through the present day.
(Imprint: Nova)

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Table of Contents

Preface

Chapter 1. Developing Aptamers for the Delivery of Therapeutic RNA
(Styliana Philippou, Nikolaos P. Mastroyiannopoulos and Leonidas A. Phylactou, Molecular Genetics, Function and Therapy Department, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, and Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus)
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Chapter 2. Aptamers as Radiopharmaceuticals
(Renata Salgado Fernandes, André Luís Branco de Barros and Antero Silva Ribeiro de Andrade, Departamento de Análises Clínicas e Toxicológicas – Faculdade de Farmácia, Universidade Federal de Minas Gerais Belo Horizonte, Minas Gerais, Brazil, and others)

Chapter 3. Aptamers vs. Antibodies in Different Detection Techniques
(Alena K. Ryabko, Maksim A. Marin, Natalia A. Zeninskaya, Victoria V. Firstova, PhD, and Igor G. Shemyakin, PhD, FBIS State Research Center for Applied Microbiology, Obolensk, Russia)

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