A Closer Look at Motor-Evoked Potential

Shapour Jaberzadeh (Editor)
Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia

Series: Neuroscience Research Progress
BISAC: MED057000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This book is an update concerning the use of transcranial magnetic stimulation (TMS) as an assessment tool for the measurement of corticospinal excitability in interventional and non-interventional studies. As a text for laboratory innovation, this book enables readers to bring their TMS laboratory to a new level of professionalism. As a less experienced TMS operator, it will assist readers in understanding the conventional and novel approaches to determination motor thresholds and help them become familiar with different uses of TMS induced motor evoked potentials (MEPs) in health and disease.

This book not only identifies the reasons behind the variability of the TMS induced MEPs, but also describes the ways to minimize this variability. It also highlights the factors affecting MEP amplitude reliability and answers the fundamental question of why the establishment of TMS operator reliability is a must in any TMS study. Reasons as to why the stimulus-response curve is a better approach for the assessment of corticospinal excitability are accentuated. A detailed step-by-step description of the single- or paired-pulse TMS protocols for the assessment of inhibitory or excitatory circuits within the brain are also provided. Finally, this book will give readers a better understanding of the risks associated with the use of TMS for both TMS operators and participants.

Preface

Acknowledgements

Chapter 1. TMS-Induced Motor Evoked Potentials: Definitions and Physiology
(Ashlyn K. Frazer, PhD and Dawson J. Kidgell, PhD, Department of Physiotherapy, School of Primary & Allied Health Care, Monash University, Melbourne, Australia)

Chapter 2. Methods for Determination of Motor Threshold
(Thusharika Dilrukshi Dissanayaka, Maryam Zoghi, PhD, Michael Farrell, PhD, Gary Egan, PhD, Shapour Jaberzadeh, PhD, Department of Physiotherapy, School of Primary & Allied Health Care, Monash University, Melbourne, Australia, and others)

Chapter 3. Variability of MEP Amplitude and Latency in Health and Disease
(Jeric Uy, PhD and Brenton Hordacre, PhD, School of Health Sciences, University of South Australia, Adelaide, Australia)

Chapter 4. Factors Affecting the Reliability of MEP Amplitude
(Shapour Jaberzadeh, PhD, and Maryam Zoghi, PhD, Department of Physiotherapy, School of Primary & Allied Health Care, Monash University, Melbourne, Australia, and others)

Chapter 5. Using Stimulus-Response Curves to Determine Corticospinal Excitability
(Dawson J. Kidgell, PhD, Department of Physiotherapy, School of Primary & Allied Health Care, Monash University, Melbourne, Australia)

Chapter 6. Applications of MEPs
(Alan J. Pearce, PhD, and Jerome J. Maller, PhD, Department of Rehabilitation, Nutition and Sport, La Trobe University, Melbourne, Australia, and others)

Chapter 7. Measuring GABAA Function in the Primary Motor Cortex
(Maryam Zoghi, PhD, and Shapour Jaberzadeh, PhD, Discipline of Physiotherapy, School of Allied Health, La Trobe University, Melbourne, Australia, and others)

Chapter 8. TMS Protocols for Assessment of GABAB Function Integrity
(Shapour Jaberzadeh, PhD, and Maryam Zoghi, PhD, Department of Physiotherapy, School of Primary & Allied Health Care, Monash University, Melbourne, Australia, and others)

Chapter 9. TMS Protocols for Assessment of Intracortical Facilitation
(Shapour Jaberzadeh, PhD, and Maryam Zoghi, PhD, Department of Physiotherapy, School of Primary & Allied Health Care, Monash University, Melbourne, Australia, and others)

Chapter 10. Safety of TMS as an Assessment Tool
(Maryam Hassanzahraee, and Maryam Zoghi, PhD, and Shapour Jaberzadeh, PhD, Department of Physiotherapy, School of Primary & Allied Health Care, Monash University, Melbourne, Australia)

Keywords: Transcranial magnetic stimulation, TMS, Motor evoked potentials, MEP, Cortico spinal excitability, Reliability, Variability, Intracortical inhibition, Intracortical facilitation

This book will serve not only as a useful methodological introduction to honours, MSC by research and PhD students and post-doctoral fellows in the field but also as a source of continual reference for more experienced TMS users.

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