A Closer Look at Kinase Inhibition

Alex Tompson (Editor)

Series: Chemistry Research and Applications
BISAC: SCI013000

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Volume 10

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Volume 2

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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A Closer Look at Kinase Inhibition opens with a discussion on the roles of various tyrosine kinases inhibitors and molecular mechanisms of acquired resistance to tyrosine kinase inhibitor drugs therapy in colon-rectal cancer.

The authors summarize host cell and viral protein kinases, the progress in their use, and the repurposing of approved kinase inhibitors as broad-spectrum antivirals.

The key kinases, namely CLK1, DYRK1A, CDK5, GSK3 and CK1, are analyzed as data indicate that targeting these proteins may have therapeutic promise against Alzheimer’s disease.
(Imprint: Nova)

Preface

Chapter 1. Targeted Therapy of Tyrosine Kinase Inhibitor Drugs for Two Different Cancers (Colon-Rectal Cancer and Chronic Myelogenous Leukemia) and Their Resistance Mechanisms
(Gabriella Marfe, Stefania Perna and Carla Di Stefano, Department of Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, University of Campania "Luigi Vanvitelli", Caserta, Italy, and others)

Chapter 2. Role of Kinases in Antiviral Therapeutics
(Vaishali M. Patil and Neeraj Masand, Drug Discovery and Interaction Center, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, Uttar Pradesh, India, and others)

Chapter 3. In Search of Novel Tau Kinase Inhibitors and Their Role in Alzheimer’s Therapy
(Arvind Kumar Jain, Saloni Malla, C. Karthikeyan, Amit K.Tiwari, Piyush Trivedid and Anita Dutt Konara, School of Pharmaceutical Sciences, Rajiv Gandhi Technological University, Bhopal, India, and others)

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