A Case-Control Study of Association between Brain-Derived Neurotrophic Factor 712G>A Polymorphism and Parkinson’s Disease

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Authors: Qiwen Liao, Peter Y. K. Poon, Anne Y. Y. Chan, Vincent C. T. Mok, and Larry Baum
Page Range: 127-133
Published in: Journal of Biochemistry and Molecular Biology in the Post Genomic Era, 2#2 (2012)
ISSN: 2156-5732

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Table of Contents

ABSTRACT

Parkinson’s disease (PD) is a progressive neurodegenerative disorder. A study reported a strong association of PD with the A allele of the -712G>A polymorphism in the Brain-derived neurotrophic factor (BDNF) gene. Therefore, we sought to confirm this finding. 261 PD patients and 199 healthy controls were genotyped using amplification refractory mutation system polymerase chain reaction (ARMS PCR). Statistical analysis was performed using the Epitools package in R software version 3.0.1. The A allele of BDNF -712G>A did not display a significant association with PD (OR = 1.00, 95% CI = 0.52-1.95, p=1.0). The BDNF -712G>A polymorphism may not affect the risk of developing PD. Further studies may help resolve the discrepancy between the previous and current reports of this association.

Keywords: Parkinson’s disease; Brain-derived neurotrophic factor; polymorphism

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