Behavioral Study of ‘Non-Opioid’ Tolerance


Merab G. Tsagareli, PhD, DScHead, Lab of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia
Nana Tsiklauri – Laboratory of Pain and Analgesia, Ivane Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia

Series: Pain Management – Research and Technology
BISAC: MED093000

Pain is a response of the body to the action of injuring stimuli. Notwithstanding an unpleasant experience, it appears to be an important component of the defense system of the organism and a permanent regulator of homeostatic reaction. The organism’s reaction to pain is a multi-component one and involves sensory-discriminative, emotional-affective and cognitive characteristics. Clinically, neuropathic pain is characterized by spontaneous ongoing or shooting pain and evoked amplified pain responses after nocuous or innocuous stimuli. The study of pain, therefore, and search for the treatment strategies have a paramount role in modern neurobiology. Numerous anatomy-physiological studies have revealed a number of brain structures involved in the shaping of pain and endogenous analgesia. This book presents and examines current research discovered in a behavioral study of ‘non-opioid’ tolerance.

Table of Contents

Table of Contents


Pain and Nociception

Ascending Pain Signal Pathways

Downstream Modulation Of Pain

Tolerance To Opioid Drugs

Periaqueductal Grey Matter

Non-Opioid Analgesics Induced Tolerance

Comparison of the Effects of Tolerance in Juvenile and Adult Rats

The Central Nucleus of Amygdala is Involved in Tolerance to the Antinociceptive Effect of NSAIDs

Tolerance Induced by Non-Opioid Analgesics

Microinjected into Periaqueductal Grey Matter

Nucleus Raphe Magnus Opioid Sensitivity to

Analgesic Effects of NSAIDs

Concluding Remarks: Brainstem

Modulation Of Nociceptive Processing



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