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Quick ViewThe major component of glycocalyx, heparan sulfate covalently attaches to proteoglycan core proteins, which is abundant at the cell surface and in the extracellular matrix. Heparan sulfate could provide binding sites on endothelial cells to retain and activate highly diffusible cytokines and inflammatory chemokines to regulate cell functions, such as proliferation and migration. Under physiological…
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Quick ViewMedicare and Medicaid provide nonemergency medical transportation (NEMT) services to eligible beneficiaries who need transportation to scheduled nonemergency care. The Centers for Medicare & Medicaid Services (CMS) administers Medicare NEMT benefits and is responsible for overseeing Medicaid at the federal level. Spending on NEMT under these programs was $2.7 billion in 2013—$1.2 billion for Medicare…
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Quick ViewThe book entitled “Lactate Dehydrogenase (LDH): Biochemistry, Functions and Clinical Significance” provides a broad and authoritative review of the lactate dehydrogenase enzyme, including its isoforms, catalytic functions, distribution in various tissues, involvement in cancer cell metabolism and tumorigenesis, involvement in the plasmodium enzyme, various small molecule inhibitors of hLDHA and pfLDH, and clinical significance. Recent…
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Quick ViewThis book provides new research insights on rare diseases. Chapter One reviews the use of patients’ registries as a key tool in rare disease management. Chapter Two discusses the worldwide experience with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with rare abdominal and pelvic neoplasms with peritoneal metastases that should be evaluated…
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Quick ViewAnesthesiology is one of the least understood medical specialties. The drugs and equipment are specialized to a point where physicians in other fields have little knowledge of how they work. Moreover, the specific techniques and concerns of anesthesiologists regarding patient care are scarcely known outside of the specialty. Most physicians have had a paltry amount…
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Quick ViewEarly Australian pioneers were blocked from advancing into the interior of the continent by the Great Dividing Range that runs along the east coast of the country. In their endeavours to expand the colonies westward and to open Australia economically, these early developers eventually found routes across the Great Dividing Range and into the interior.…
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Quick ViewPhytomedicines have been playing an important role since the beginning of civilization, curing many diseases and alleviating different symptoms for the wellbeing of humans and animals. The millenary history of medicinal plant use and its derivatives give credibility to the development of new and advanced pharmaceutical forms of phytomedicines, which may play an important role…
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Quick ViewPain is considered one of the most relevant symptoms of musculoskeletal disorders (MSD). Myofascial pain with taut bands and trigger points (TrPs) of muscles involved is common in the medical practice. Myofascial pain arises by overuse, strain and exhaustion of muscle and after precision work. Chapter One conjectures that these factors cause sustained activity of…
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Quick ViewCaenorhabditis elegans – An Overview and Emerging Roles in Studying Disease explores different disease models that have been successfully validated in this nematode, either to unravel disease mechanisms or to perform drug screenings. This nonpathogenic organism has helped to firstly identify genetic mechanisms important in cancer (Ras and Bcl oncogene signaling), aging (insulin signaling), and…
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Quick ViewThis new book provides a new outlook on the practice of palliative care worldwide. All five continents are represented in this book by global leaders in this relatively new subspecialty. The chapters in the book re-emphasize the fact that in the 21st century, most patients in the world still lack this elementary tool to alleviate…
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Quick ViewThe I. Beritashvili Center of Experimental Biomedicine was established in 2010 on the basis of merging four well-known Georgian research institutes. They are: The I. Beritashvili Institute of Physiology, one of the most prominent research centers of Georgia, where basic and applied research in different fields of neurophysiology has been conducted since 1935; the Institute…
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Quick ViewThere is a critical and continuing shortage of organs and cells from deceased human donors for the purposes of transplantation into patients with terminal organ failure. The use of organs and cells from pigs – i.e., cross-species transplantation, or xenotransplantation – could resolve this problem. Recollections of Pioneers in Xenotransplantation Research is a collection of…
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