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Quick ViewThe study on molecular rotors and motors is a hot research topic in the current era of nanotechnology. Internal rotation is a ubiquitous motion in most molecules and is considered a bridge to interconnect different energy forms. This monograph is focused on the computational studies on the molecular dynamics of the internal rotation of methyl,…
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Quick ViewIn the post-genomic era, science is still challenged to explain the biosynthesis of complex polysaccharides and glycoconjugates. Unlike nucleic acids and proteins, the information needed for their biosynthesis is not clearly contained to this day within the genome of the various organisms. This means that no biosynthetic code has been revealed yet. As a result,…
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Quick ViewCyclodextrins (CDs) are capable of interacting with a large variety of guest molecules to form inclusion complexes. The authors of the chapters that form this book discuss the development of ion-selective electrodes based on selected cyclodextrins and their derivatives as selective ionophores for various drugs and their applications in pharmaceutical research; the wide range of…
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Quick ViewEicosanoids constitute a large and expanding family of bioactive lipids synthesized from polyunsaturated fatty acids (PUFA) to either pro-inflammatory omega-6 arachidonic acid (AA) or anti-inflammatory omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In these last cases, two essential fatty acids (FAs) (ω-6 linoleic acid (C18:2n6) and ω-3 linolenic acid (LA) (C18:3n3) are utilized as…
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Quick ViewCirculating tumor cells (CTCs) are the seeds for cancer metastases development, which is responsible for >90% of cancer-related deaths. Accurate quantification of CTCs in human fluids could be an invaluable tool for understanding cancer prognosis, delivering personalized medicine to prevent metastasis and finding cancer therapy effectiveness. Although CTCs were first discovered more than 200 years…
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Quick ViewTrehalose as a natural disaccharide presents in plants, invertebrates, fungi and prokaryotes, but not in mammals. A white, odorless, crystalline powder with a sweet taste, it is best known as a source of energy and protectant to survive harsh environmental conditions in many organisms, but its applications cover a wide array of disciplines. Research engagement…
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Quick ViewSensorial neurons activate the locus coeruleus long axons for a presynaptic Ca2+-dependent release of noradrenaline (NA). Postsynaptic adenylyl cyclase (AC) of several areas of the brain shows Mg2+-dependent responsiveness to the neurotransmitter in the absence of Ca2+ when the free Mg2+ is present in excess of substrate Mg-ATP. The brain capillary glucose uptake by red-cells…
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