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Quick ViewPoorly differentiated triple negative breast cancers (TNBCs) were first characterized in the literature in 2005 by the absence of receptors for estrogen (ER) and progesterone (PR) as well as the lack of tyrosine kinase human epidermal growth factor receptor 2 (HER-2). Clinically, TNBCs exhibit fairly aggressive local growth, rapid progression and account for a high…
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Quick ViewAs a new concept of cancer treatment, photodynamic therapy (PDT) has gained great attention in the last few decades. Compared to classical treatments such as surgery, chemotherapy and radiotherapy, PDT is a noninvasive, localized treatment of lesions that shows fewer side effects and has low systemic toxicity. In Chapter One, the basic mechanisms, applications and…
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Quick ViewCutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of Non-Hodgkin lymphomas with a variety of clinical presentation and outcomes. The diagnosis and treatment of CTCLs have evolved significantly with advances in our understanding of their pathogenesis and biological behaviors through immunophenotypic, molecular, and cytogenetic analysis and clinical correlation. The diagnosis and classification of CTCLs depend…
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Quick ViewThis book aims to assist the scientists working with the medicinal, biochemical, biophysical, genetic and pharmacological aspects of topoisomerases and their inhibitors. The book has covered various aspects of topoisomerases like classification, structural aspects, basic genetics and mutations, disease implications and cell signaling networks, which may be helpful for researchers of the field for better…
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Quick ViewHigh-grade gliomas are the most frequent primitive brain malignancies of the adult and account for approximately 60-75% of all gliomas. Chapter One concludes the progress in the management of high-grade gliomas requires the simultaneous and synergic effort of a multitude of health professionals including neurosurgeons, neuroncologists, neurointerventionalists, radiologists, immunologists and neuropathologists among others. Chapter Two…
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Quick ViewWith advances in knowledge and technology, the proportion of cancer patients who have been cured or survive with cancers is growing, but a certain proportion of patients will still have disease recurrence or progression to palliative care. During the entirety of cancer progression, significant adverse impacts on physical and psychological aspects have been observed due…
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Quick ViewChemoprevention is the use of tiny molecules that include nutritional substances or herbal products to avoid cancers. They are different from chemotherapeutics, where synthetic chemicals are used to eliminate or improve cancer progression. Numerous clinical trials have established the efficiency of using raloxifene and tamoxifen (both are estrogen receptor antagonists), and fenretinide, an artificial retinoid…
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Quick ViewThe Epstein-Barr Virus (EBV), also known as Human Herpes Virus 4, has been identified and described as the etiological agent of infectious mononucleosis. It is the first human virus found to be implicated in oncogenesis. EBV is associated with a number of biologically diverse cancers, mainly lymphoproliferations of B-cell origin. With the development of basic…
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Quick ViewAbout 40% of the population in the industrialized world will develop cancer at some point in their lives,and about half of these people will be cured. Unfortunately, however, approximately one in four Americans alone will die from cancer (over 560,000 Americans each year). Tomasetti and Vogelstein have recently reported that nearly two-thirds of all cancers…
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Quick ViewIn the first chapter, I-Ling Hung, Yu-Chiang Hung, and Wen-Long Hu examine the synergistic processes of herbal ingredients in order to help researchers discover new phytomedicines. Next, in the second chapter, Muhammad Imran Qadir gives a synopsis of the discussion regarding the cure of developed prostate cancer by using androgen deprivation therapy. Ddiethylstilbestrol was previously…
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Quick ViewCancer risk prediction models provide an important approach to assess risk and susceptibility by identifying individuals at high risk, facilitating the design and planning of clinical chemoprevention trials, and allowing the evaluation of interventions. Conventional breast cancer risk model includes the cumulative estrogen exposure data such as age, age at menarche and menopause, age at…
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Quick ViewBreast cancer is the most frequently diagnosed type of cancer and the second leading cause of cancer death in women after lung cancer. It is estimated that breast cancer affects more than 1,000,000 women worldwide each year, and about 450,000 die from the disease. During the last decades, breast cancer has received considerable attention, yet…
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Quick ViewBrain metastases are frequently encountered in the neuro-oncological field. It has been estimated that 170,000 people a year in the USA experience this condition. Moreover, brain metastases are four times more frequently encountered than primitive cerebral tumors, and will increase in the future due to systemic cancer patients management. This book presents current biological viewpoints,…
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Quick ViewEndometrial cancer is the most common cancer of the female reproductive system, with more than 49,500 United States women that are diagnosed with the disease each year. It tends to develop after menopause, when a woman is between the ages of 50 and 60. It is the sixth most common cancer in women worldwide (fourteenth…
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Quick ViewThe 3O2 generated by the photolysis process will accept enough energy from triplet-chlorophyll to provide the energy states of a singlet of oxygen (1O2), 1Δg, and 1Σg+, with emissions in the range of 200 – 500 µm. The 1O2 would react with unsaturated fatty acids to form malondialdehyde (MDA). In humans, the methylation of CpG…
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Quick ViewIn the age of constant knowledge via computer accessibility, the effort to write a book on adjuvant chemotherapy may seem almost futile. However, the information seen online is usually fragmented, without context, and often somewhat unreliable. This book aims to provide a handy and reliable reference to better understand both the current situation and the…
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Quick ViewPancreatic cancer is a very aggressive carcinoma with a poor prognosis. From all options currently available for pancreatic cancer patients, surgical resection offers the only potential for a cure. The high mortality rate of pancreatic cancer is related to the advanced stage of disease at the time of diagnosis. However, it is extraordinarily difficult to…
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Quick ViewMany cancers are associated with the abnormal production of some molecules which can be measured in plasma/urine or can be detected on the surface of resected tumor tissue. These molecules are known as tumor markers. The potential uses of tumor markers are screening in the general population, differential diagnoses of symptomatic patients, clinical staging of…
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Quick ViewThe Sentinel Lymph Node: Detection, Procedures and Clinical Implications gathers an overview of the sentinel lymph node biopsy procedure among different surgical settings (i.e., melanoma, breast, thyroid, vulva, endometrium, cervix, colon, anus, liver, gastric, urological and ovarian cancers). This book consists of eighteen chapters; the rationale and the purpose of this technique, which allows adequate…
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Quick ViewEndometrial cancer is the most common gynecological cancer and the sixth cause of cancer in developed countries. The findings that EC is a heterogeneous group of tumors with distinct risk factors and histopathological features, together with our improved understanding of its molecular mechanism has paved the way to the investigation of new surgical and medical…
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Quick ViewLaryngeal cancer is one of the most common cancers of the head and neck. The best diagnostic approach is provided by performing a full endoscopic evaluation, appropriate imaging and biopsy. Therapy can thereafter be tailored to pathology, stage of disease, and then individualized. The multidisciplinary tumor board represents an essential requirement in oncologic diagnosis and…
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Quick ViewThis monograph is dedicated to the issues of clinical oncoproteomics, its role and place in contemporary medicine in general, and in particular, oncology. This book reviews various academic viewpoints on the informational component and value of the data of clinical oncoproteomics for the diagnostics and treatment of malignant tumors using cellular, genomic and post-genomic technologies.…
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Quick ViewBladder cancer is the fifth most common cancer with an estimated 60,490 new cases and 12,240 deaths expected for 2017 in the US alone. The diagnosis and treatment of bladder cancer in the current era is in the midst of a revolution. Recent research has focused on the evaluation of genetic markers to provide diagnostic…
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Quick ViewHorizons in Cancer Research. Volume 69 opens with a discussion on hypothetical mechanisms of the induction of NKreg cells in cancer and possible approaches to their abrogation, suggesting that for profound understanding of the problem of NKregs in the context of future target cancer immunotherapy, extensive clinical observations of NKreg cells should be carried out.…
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