New Review

“Diarrhea, whose morbidity is still a non-solved problem, still creates a great deal of anxiety among parents who look for something to stop the disease as quickly as possible. Racecadotril fulfills all the characteristics that an ideal antidiarrheal drug should have, as described by Dr. Robert Edelman in 1985, when adequate antidiarrheal drugs were not yet available. Taken by mouth, racecadotril is rapidly absorbed in the intestine and found subsequently in large quantities in the submucosal structures of the intestinal wall. It inhibits the enkephalinase activity, protects enkephalins from inactivation, reduces cytosolic cyclic AMP level, and rapidly controls hypersecretion of water and electrolytes without affecting the intestinal motility. Furthermore, it does not cross the blood-brain barrier and thus has no sedative effects. This book, edited by Dr. Marco Manfredi, is a comprehensive review of racecadotril. A group of experts in the field reviews its history, pharmacologic properties, mode of action, and results of clinical trials conducted to prove its efficacy and safety. It is particularly remarkable to have among the authors, Dr. Schwartz and Dr. Lecomte, who were the developers of this drug. Time will prove that this book is an excellent addition to the bookshelf of those who have an interest in the field of diarrheal diseases and its treatment.”

Eduardo Salazar-Lindo, MD
Professor of Pediatrics
Universidad Peruana Cayetano Heredia
Lima, Peru