Jaundice or icterus is a commonly widespread disease condition of newborn child or neonates especially in underdeveloped countries across the globe. Generally, the term jaundice is derived from the French word “jaune”, which means “yellowness” accentuated by yellow pigmentation. The major manifestation is the yellow discoloration of the skin and mucous membrane tissue associated with the excessive accumulation of bilirubin levels in the bloodstream and this condition is called hyperbilirubinemia. According to the recent statistical analysis, 14.1 million newborns (10.5% of live births) require phototherapy for jaundice; amongst them, 6 million do not have access to treatment and 2.4 million without access to treatment are primarily in Central and South Asia on a global level. In India, 15.3% of neonatal admissions of severe jaundice, with a CFR of 6.7%, leading to 4.4% of the deaths and encountered a mortality rate of 7.3/1,000 live births in Indian rural areas. In particular, it is most fatal in newborns, although, the disease is not very much common in adults.